Les Projets de
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Present Research Projects
Healthy Water, home page.
overall goal of the project is to advance our knowledge on pathogenesis
of emergent microbial pathogens in drinking water and to understand
their transmission to humans. The project will focus on all major types
of pathogens, i.e. viruses, bacteria and protozoa, and will concentrate
on a representative set of European drinking water supply systems and
source waters of specific sensitivity to human health. This project
will build on the output of the MicroRisk project by focussing on water
systems that are in general not as well protected as the systems within
MicroRisk. To reach the overall goal the following detailed objectives
are approached: 1. Validation and application of detection technologies
for emerging microbial pathogens based on nucleic acids. 2. Molecular
survey and comparative detailed study of emerging pathogens in European
drinking water sources and supply systems. 3. Understanding the human
health impact of emerging pathogens by primary epidemiological studies
targeted at specific systems and pathogens. 4. Determination of
epidemiological correlations with molecular and environmental data and
assessment of risk for waterborne microbial infections in Europe. An
integrated research approach will be pursued to achieve these
objectives by combining molecular and classical detection, activity
assessment and epidemiological understanding of emerging pathogens in a
specific set of drinking water systems from different European regions.
The project will generate validated detection technologies for the
targeted waterborne pathogens and reveal possible routes of
transmission to humans via drinking water consumption. This new
knowledge will provide guidance to improve the hygienic quality of
European drinking water supplies and reduce the burden of waterborne
infections for the people in Europe.
To meet the general aim given by the
Commission we have defined the following specific
objectives within the HEALTHY-WATER project:
Objective 1: Development and
validation of molecular detection
technologies for emerging microbial pathogens
based on nucleic acids to provide a format ready for mass application in drinking
Objective 2: Molecular survey and
comparative detailed study of emerging
microbial pathogens in European drinking water sources and supply
Objective 3: Understanding human
health impacts of emerging pathogens in
different drinking water supply systems and different supply
Objective 4: Determination of
epidemiological correlations with molecular and
environmental data and assessment of risk for emerging
waterborne microbial infections in Europe.
AQUAPARADOX, home page.
The Paradox of the Plankton (G. E. Hutchinson 1961. Amer Nat 95:137-145)
"...... how is it possible for a number of species to coexist in a
relatively isotropic or unstructured environment all competing for the
same sort of materials. The problem is particularly acute because there
is adequate evidence from enrichment experiments that natural waters,
at least in the summer, present an environment of striking nutrient
deficiency, so that competition is likely to be extremely severe."
AQUAPARADOX Project Summary
Planktonic microbes constitute the base of aquatic ecosystems. Protists
are typical of the plankton as species richness seems unreasonably
high- the 'Paradox'. In addition, each species appears widely
distributed. Recent molecular data suggest that protist species,
defined morphologically, may be genetically diverse. Thus, many
'species' of planktonic protists actually may be groups of cryptic
species (morphologically indistinguishable, genetically divergent) each
adapted to precise ecological niches. Conversely, many species have
been catalogued which might be simply variants of a single species. In
this project, we will examine morphological, genetic and physiological
diversity in common coastal protist morpho-species, that is
morphologically-defined species. Subjects of study include a wide range
of protists: 1) grazers of the sea- tintinnid ciliates, 2) autotrophs,
that is 'plant' or phytoplankton forms- the dinoflagellate Ceratium and
the small flagellate Micromonas, and 3) the parasite Syndiniales.
Population structure of protist species will be studied at the level of
single cells and between populations separated by different scales of
time and space. Genetic diversity will be evaluated using SSU rRNA, ITS
sequences and protein coding genes. Morphometrics will be used to
characterise variability within a species and physiological adaptation
using cultures. We will also examine patterns of community assembly and
historical trends in species distributions. Our goal is to provide a
basis for understanding protist adaptation, speciation and ecology in
Phylogeny and biodiversity.
diversity: the new approach. (in french)
importance of the microbial world (french).
build a molecular
systematics of microbes : molecular phylogenies (french).
and DNA chips (french).
ontologies to asses microbial diversity and activities (english).
Pyrosequencing it all
Design of DNA chips.
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last updated 2008.